Abstract
Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; however, whether this is protective or pathogenic remains to be determined. Defining the immunopathological changes in patients with COVID-19 provides potential targets for drug discovery and is important for clinical management. In the short time since SARS-CoV2 emerged, much has been learned about the immunopathology of the infection. Here, Xuetao Cao discusses what these early insights imply for drug discovery and clinical management.
Keywords
ImmunopathologyCytokine stormCoronavirus disease 2019 (COVID-19)PneumoniaImmunologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakMedicineDiseaseCytokineVirologyInfectious disease (medical specialty)PathologyInternal medicine
MeSH Terms
AntibodiesMonoclonalHumanizedAntiviral AgentsCOVID-19Clinical Trials as TopicCoronavirus InfectionsCytokinesHumansImmunizationPassiveInflammationMesenchymal Stem Cell TransplantationPandemicsPneumoniaViralCOVID-19 Serotherapy
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Publication Info
- Year
- 2020
- Type
- review
- Volume
- 20
- Issue
- 5
- Pages
- 269-270
- Citations
- 1680
- Access
- Closed
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Cite This
Xuetao Cao
(2020).
COVID-19: immunopathology and its implications for therapy.
Nature reviews. Immunology
, 20
(5)
, 269-270.
https://doi.org/10.1038/s41577-020-0308-3
Identifiers
- DOI
- 10.1038/s41577-020-0308-3
- PMID
- 32273594
- PMCID
- PMC7143200