The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

Abstract

Abstract This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell–driven disease that presents with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous or inducible urticaria is disabling, impairs quality of life, and affects performance at work and school. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert‐guided and evidence‐based diagnostic and therapeutic approaches for the different subtypes of urticaria.

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Affiliated Institutions

• Sociedade Brasileira de Cardiologia BR
• University of Southern Denmark DK
• Assistance Publique – Hôpitaux de Paris FR
• Peking University First Hospital CN
• Montreal Children's Hospital CA
• Helsinki University Hospital FI
• Universidade Federal do Paraná BR
• Hospital Médica Sur MX
• Sorbonne Université FR
• University of Debrecen HU
• University College London GB
• Université Laval CA
• Koç University TR
• University of Toronto CA
• Charité - Universitätsmedizin Berlin DE
• University of Groningen NL
• Long Island University US
• Kantonsspital St. Gallen CH
• University of Copenhagen DK
• Technical University of Munich DE
• Fraunhofer Institute for Translational Medicine and Pharmacology DE
• Freie Universität Berlin DE
• Humboldt-Universität zu Berlin DE
• Centre d'Immunologie et des Maladies Infectieuses FR
• Mahidol University TH
• Kuopio University Hospital FI
• Smolensk State Medical University RU
• Istanbul University TR
• Guy's Hospital GB
• University of Helsinki FI
• Bispebjerg Hospital DK
• Dermatology Research Center US
• McGill University CA
• Hospital Juárez de México MX
• Nippon Medical School JP
• Hacettepe University TR
• Medical University of South Carolina US
• Mater Dei Hospital MT
• Faculdade de Medicina do ABC BR
• Odense University Hospital DK
• Universitair Ziekenhuis Brussel BE
• St. Michael's Hospital CA
• University of Milan IT
• D.Y. Patil University IN
• Aarhus University Hospital DK
• Vrije Universiteit Brussel BE
• Siriraj Hospital TH
• Ospedale San Carlo IT
• University of Opole PL
• Hiroshima University JP
• Universidad Nacional de Asunción PY
• University of Coimbra PT
• Hospital Kuala Lumpur MY
• Universitat Pompeu Fabra ES
• Peking University CN
• University of Southampton GB
• Federal Medical-Biological Agency RU
• Medical University of Vienna AT
• University of Cincinnati US
• Inserm FR
• University Medical Center of the Johannes Gutenberg University Mainz DE
• Abu Dhabi Health Services AE
• University Hospital of Zurich CH
• Hospital del Mar Research Institute ES
• University of Perugia IT
• Universidade Federal de São Paulo BR
• Hiroshima City Asa Citizens Hospital JP
• Hôpital Tenon FR
• Johannes Gutenberg University Mainz DE
• University General Hospital Attikon GR
• New York University US
• Centre hospitalier universitaire de Québec CA
• Bnai Zion Medical Center IL
• National and Kapodistrian University of Athens GR
• Medizinische Hochschule Hannover DE
• The Royal Free Hospital GB

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