Abstract

Unveiling the Zika virus The ongoing Zika virus epidemic is of grave concern because of its apparent links to congenital microcephaly and Guillain-Barré syndrome. Sirohi et al. present a near-atomic-resolution structure of mature Zika virus determined by cryo-electron microscopy. The structure is mainly similar to that of other flaviviruses such as dengue virus; however, there are differences in a region that may be involved in binding to host receptors. The structure provides a foundation for analysis of the antigenicity and pathogenesis of Zika virus. Science , this issue p. 467

Keywords

Zika virusFlavivirusVirologyDengue feverVirusVirus classificationMicrocephalyDengue virusBiologyFlaviviridaeYellow feverCryo-electron microscopyViral diseaseGeneticsBiophysicsGenome

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Publication Info

Year
2016
Type
article
Volume
352
Issue
6284
Pages
467-470
Citations
726
Access
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Devika Sirohi, Zhenguo Chen, Lei Sun et al. (2016). The 3.8 Å resolution cryo-EM structure of Zika virus. Science , 352 (6284) , 467-470. https://doi.org/10.1126/science.aaf5316

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DOI
10.1126/science.aaf5316