Abstract

The family Flaviviridae comprises the genus Flavivirus, which contains 65 related species and two possible members. They are small, enveloped RNA viruses (diameter 45 nm) with peplomers comprising a single glycoprotein E. Other structural proteins are designated C (core) and M (membrane-like). The single strand of RNA is infectious and has a molecular weight of about 4 X 10(6) and an m7G 'cap' at the 5' end but no poly(A) tract at the 3' end; it functions as the sole messenger. The gene sequence commences 5'-C-M-E.... The replication strategy and the mode of morphogenesis are distinct from those of the Togaviridae which are slightly larger and morphologically similar in some respects. Flaviviruses infect a wide range of vertebrates, and many are transmitted by arthropods.

Keywords

BiologyTogaviridaeFlavivirusVirologyFlaviviridaeRNAGeneVirusGeneticsHepatitis C virus

MeSH Terms

AlphavirusAnimalsEndoplasmic ReticulumFlavivirusGenesViralMorphogenesisRNAViralViral Core ProteinsViral Envelope ProteinsViral Matrix ProteinsViral ProteinsVirus Replication

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Publication Info

Year
1985
Type
review
Volume
24
Issue
4
Pages
183-192
Citations
351
Access
Closed

External Links

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Cite This

E. G. Westaway, Margo A. Brinton, Ya. Gaidamovich et al. (1985). Flaviviridae. Intervirology , 24 (4) , 183-192. https://doi.org/10.1159/000149642

Identifiers

DOI
10.1159/000149642
PMID
3000978

Data Quality

Data completeness: 81%