Spatial partitioning of the regulatory landscape of the X-inactivation centre

Elphège P. Nora; Bryan R. Lajoie; Edda G. Schulz; Luca Giorgetti; Ikuhiro Okamoto; Nicolas Servant; Tristan Piolot; Nynke L. van Berkum; Johannes Meisig; John W. Sedat; Joost Gribnau; Emmanuel Barillot; Nils Blüthgen; Job Dekker; Édith Heard

doi:10.1038/nature11049

Keywords

XISTChromosome conformation captureChromatinX-inactivationBiologyGenomeX chromosomeGeneticsComputational biologyGenomic organizationGeneEvolutionary biologyTranscription factorEnhancer

Affiliated Institutions

Related Publications

The macrosatellite DXZ4 mediates CTCF-dependent long-range intrachromosomal interactions on the human inactive X chromosome

Andrea Harničarová Horáková , Shawn C. Moseley , Christine R McLaughlin +2 more

The human X-linked macrosatellite DXZ4 is a large tandem repeat located at Xq23 that is packaged into heterochromatin on the male X chromosome and female active X chromosome and...

2012 Human Molecular Genetics 76 citations

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Erez Lieberman-Aiden , Nynke L. van Berkum , Louise Williams +16 more

Chromosomal Mapping The conformation of the genome in the nucleus and contacts between both proximal and distal loci influence gene expression. In order to map genomic contacts,...

2009 Science 9165 citations

Position effect variegation and chromatin proteins

Gunter Reute , Pierre Spierer

Abstract Variegated phenotypes often result from chromosomal rearrangements that place euchromatic genes next to heterochromatin. In such rearrangements, the condensed structure...

1992 BioEssays 308 citations

The Spatial Organization of the Human Genome

Wendy A. Bickmore

In vivo, the human genome functions as a complex, folded, three-dimensional chromatin polymer. Understanding how the human genome is spatially organized and folded inside the ce...

2013 Annual Review of Genomics and Human G... 415 citations

Evolution of the mammalian transcription factor binding repertoire via transposable elements

Guillaume Bourque , Bernard Leong , Vinsensius B. Vega +8 more

Identification of lineage-specific innovations in genomic control elements is critical for understanding transcriptional regulatory networks and phenotypic heterogeneity. We ana...

2008 Genome Research 611 citations

Publication Info

Year: 2012
Type: article
Volume: 485
Issue: 7398
Pages: 381-385
Citations: 3094
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Spatial partitioning of the regulatory landscape of the X-inactivation centre

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

3094

OpenAlex

Cite This

APA Style

                            
                                
                                    Elphège P. Nora, 
                                
                                    Bryan R. Lajoie, 
                                
                                    Edda G. Schulz
                                
                                et al.
                            
                            (2012). 
                            Spatial partitioning of the regulatory landscape of the X-inactivation centre. 
                            Nature
                            , 485
                            (7398)
                            , 381-385.
                            https://doi.org/10.1038/nature11049
                        

Identifiers

DOI: 10.1038/nature11049