Abstract
In vivo, the human genome functions as a complex, folded, three-dimensional chromatin polymer. Understanding how the human genome is spatially organized and folded inside the cell nucleus is therefore central to understanding how genes are regulated in normal development and dysregulated in disease. Established light microscopy–based approaches and more recent molecular chromosome conformation capture methods are now combining to give us unprecedented insight into this fascinating aspect of human genomics.
Keywords
Human genomeGenomeChromatinChromosome conformation captureGenomicsComputational biologyBiologyHuman diseaseHuman cellEvolutionary biologyGenomic organizationGeneGeneticsGene expression
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Publication Info
- Year
- 2013
- Type
- review
- Volume
- 14
- Issue
- 1
- Pages
- 67-84
- Citations
- 415
- Access
- Closed
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Cite This
Wendy A. Bickmore
(2013).
The Spatial Organization of the Human Genome.
Annual Review of Genomics and Human Genetics
, 14
(1)
, 67-84.
https://doi.org/10.1146/annurev-genom-091212-153515
Identifiers
- DOI
- 10.1146/annurev-genom-091212-153515