Abstract
SMART is a simple modular architecture research tool and database that provides domain identification and annotation on the WWW (http://coot.embl-heidelberg.de/SMART). The tool compares query sequences with its databases of domain sequences and multiple alignments whilst concurrently identifying compositionally biased regions such as signal peptide, transmembrane and coiled coil segments. Annotated and unannotated regions of the sequence can be used as queries in searches of sequence databases. The SMART alignment collection represents more than 250 signalling and extracellular domains. Each alignment is curated to assign appropriate domain boundaries and to ensure its quality. In addition, each domain is annotated extensively with respect to cellular localisation, species distribution, functional class, tertiary structure and functionally important residues.
Keywords
BiologyAnnotationComputational biologyDomain (mathematical analysis)Identification (biology)Transmembrane domainModular designSequence (biology)Protein domainDatabaseSequence alignmentPeptide sequenceBioinformaticsGeneticsComputer scienceGene
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Publication Info
- Year
- 1999
- Type
- article
- Volume
- 27
- Issue
- 1
- Pages
- 229-232
- Citations
- 330
- Access
- Closed
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Cite This
Chris P. Ponting,
J. Schultz,
Frank Milpetz
et al.
(1999).
SMART: identification and annotation of domains from signalling and extracellular protein sequences.
Nucleic Acids Research
, 27
(1)
, 229-232.
https://doi.org/10.1093/nar/27.1.229
Identifiers
- DOI
- 10.1093/nar/27.1.229