Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

Abstract

Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which the genetic underpinnings of these diseases differ or overlap is unknown. Gandal et al. performed meta-analyses of transcriptomic studies covering five major psychiatric disorders and compared cases and controls to identify coexpressed gene modules. From this, they found that some psychiatric disorders share global gene expression patterns. This overlap in polygenic traits in neuropsychiatric disorders may allow for better diagnosis and treatment. Science , this issue p. 693

Keywords

Affiliated Institutions

• Mental Health Services DK
• University of Chicago US
• Center for Autism and Related Disorders US
• University of California, Los Angeles US
• Tempus Labs (United States) US
• Central South University CN
• University of Illinois Chicago US
• Lundbeck Foundation DK
• University of Copenhagen DK

Related Publications