Abstract

Eukaryotic cells react to potentially dangerous perturbations of the intracellular or extracellular microenvironment by activating rapid (transcription-independent) mechanisms that attempt to restore homeostasis. If such perturbations persist, cells may still try to cope with stress by activating delayed and robust (transcription-dependent) adaptive systems, or they may actively engage in cellular suicide. This regulated form of cell death can manifest with various morphological, biochemical and immunological correlates, and constitutes an ultimate attempt of stressed cells to maintain organismal homeostasis. Here, we dissect the general organization of adaptive cellular responses to stress, their intimate connection with regulated cell death, and how the latter operates for the preservation of organismal homeostasis.

Keywords

HomeostasisCell biologyProgrammed cell deathBiologyTranscription factorIntracellularTranscription (linguistics)ExtracellularCellNeuroscienceGeneApoptosisGenetics

MeSH Terms

ApoptosisAutophagyEukaryotic CellsHomeostasisMitochondriaNecrosisSignal TransductionStressPhysiological

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Publication Info

Year
2016
Type
review
Volume
73
Issue
11-12
Pages
2405-2410
Citations
166
Access
Closed

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Cite This

Lorenzo Galluzzi, José Manuel Bravo‐San Pedro, Oliver Kepp et al. (2016). Regulated cell death and adaptive stress responses. Cellular and Molecular Life Sciences , 73 (11-12) , 2405-2410. https://doi.org/10.1007/s00018-016-2209-y

Identifiers

DOI
10.1007/s00018-016-2209-y
PMID
27048813
PMCID
PMC11108439

Data Quality

Data completeness: 86%