M. Celeste Simon

The tumor microenvironment

A tumor is not simply a group of cancer cells, but rather a heterogeneous collection of infiltrating and resident host cells, secreted factors and extracellular matrix. Tumor ce...

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

Glutathione metabolism in cancer progression and treatment resistance

Glutathione (GSH) is the most abundant antioxidant found in living organisms and has multiple functions, most of which maintain cellular redox homeostasis. GSH preserves suffici...

Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis

Hypoxic response and inflammation both involve the action of the hypoxia-inducible transcription factors HIF-1α and HIF-2α. Previous studies have revealed that both HIF-α protei...