Pan-cancer single-cell landscape of tumor-infiltrating T cells

Abstract

An atlas of cancer-associated T cells The tumor microenvironment contains many different kinds of immune cells, the composition, function, and roles of which are unclear. Using single-cell RNA sequencing of T cells in 21 cancer types from more than 300 patients, Zheng et al . identified differences in transcript composition that could be used to catalog different T cell types (see the Perspective by van der Leun and Schumacher). These annotations identified the different roles of specific types of CD4 + and CD8 + T cells among the different tumor types. Some of these clusters revealed evidence for two developmental paths for T cells, one of which shows a trajectory toward the “exhausted” T cell state, knowledge of which may be useful in developing future cancer immunotherapies. —LMZ

Keywords

Affiliated Institutions

• Peking University Third Hospital CN
• Center for Life Sciences CN
• Peking University Cancer Hospital CN
• Peking University CN
• Analytical Biosciences (China) CN

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