On the role of helper lipids in lipid nanoparticle formulations of siRNA

Jayesh A. Kulkarni; Dominik Witzigmann; Jerry Leung; Yuen Yi C. Tam; Pieter R. Cullis

doi:10.1039/c9nr09347h

Abstract

In empty LNP formulations, DSPC–cholesterol resides in outer layers, whereas in loaded systems some of the DSPC–cholesterol is internalized together with siRNA.

Keywords

NanoparticleNanotechnologyChemistryBiophysicsMaterials scienceBiology

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Publication Info

Year: 2019
Type: article
Volume: 11
Issue: 45
Pages: 21733-21739
Citations: 344
Access: Closed

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APA Style

                            
                                
                                    Jayesh A. Kulkarni, 
                                
                                    Dominik Witzigmann, 
                                
                                    Jerry Leung
                                
                                et al.
                            
                            (2019). 
                            On the role of helper lipids in lipid nanoparticle formulations of siRNA. 
                            Nanoscale
                            , 11
                            (45)
                            , 21733-21739.
                            https://doi.org/10.1039/c9nr09347h
                        

Identifiers

DOI: 10.1039/c9nr09347h