Abstract

Nanoparticles with widely varying physical properties and origins (spherical versus irregular, synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus large) have been previously noted to translocate across the cell plasma membrane. We have employed atomic force microscopy to determine if the physical disruption of lipid membranes, formation of holes and/or thinned regions, is a common mechanism of interaction between these nanoparticles and lipids. It was found that a wide variety of nanoparticles, including a cell penetrating peptide (MSI-78), a protein (TAT), polycationic polymers (PAMAM dendrimers, pentanol-core PAMAM dendrons, polyethyleneimine, and diethylaminoethyl-dextran), and two inorganic particles (Au-NH2, SiO2-NH2), can induce disruption, including the formation of holes, membrane thinning, and/or membrane erosion, in supported lipid bilayers.

Keywords

Cationic polymerizationLipid bilayerNanoparticleNanotechnologyChemistryMaterials scienceChemical engineeringBiophysicsMembranePolymer chemistryBiochemistryBiology

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Publication Info

Year
2008
Type
article
Volume
8
Issue
2
Pages
420-424
Citations
543
Access
Closed

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Pascale R. Leroueil, Stephanie A. Berry, Kristen Duthie et al. (2008). Wide Varieties of Cationic Nanoparticles Induce Defects in Supported Lipid Bilayers. Nano Letters , 8 (2) , 420-424. https://doi.org/10.1021/nl0722929

Identifiers

DOI
10.1021/nl0722929