Abstract

Peroxynitrite can nitrate tyrosine residues of proteins. We examined nitrotyrosine-containing proteins in cerebrospinal fluid of 66 patients with neurogenic disease by immunoblot analysis. Nitrated tyrosine residue-containing protein was observed in the cerebrospinal fluid and was concluded to be manganese superoxide dismutase (Mn-SOD). The nitrated Mn-SOD level was strikingly elevated in amyotrophic lateral sclerosis patients and was slightly increased in Alzheimer's and Parkinson's disease patients, whereas an elevated Mn-SOD level was observed only in progressive supranuclear palsy group.

Keywords

Amyotrophic lateral sclerosisSuperoxide dismutasePeroxynitriteOxidative stressCerebrospinal fluidChemistryNitrotyrosineDismutaseTyrosineBiochemistryPathologySuperoxideMedicineEnzymeDiseaseNitric oxide synthase

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Year
2000
Type
article
Volume
47
Issue
4
Pages
524-527
Citations
130
Access
Closed

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Koji Aoyama, Kazuo Matsubara, Yasunori Fujikawa et al. (2000). Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases. Annals of Neurology , 47 (4) , 524-527. https://doi.org/10.1002/1531-8249(200004)47:4<524::aid-ana19>3.0.co;2-5

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DOI
10.1002/1531-8249(200004)47:4<524::aid-ana19>3.0.co;2-5