Irwin Fridovich

Superoxide Dismutase

An enzyme which catalyzes the dismutation of superoxide radicals (O2·- + O2·- + 2H+ → O2 + H2O2) has been purified by a simple procedure from bovine erythrocytes. This enzyme, c...

The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase

The rate of autoxidation of epinephrine and the sensitivity of this autoxidation to inhibition by superoxide dismutase were both augmented, as the pH was raised from 7.8 → 10.2....

Superoxide Dismutase

Abstract Fresh chicken liver contains two types of superoxide dismutase, one of which is localized in the mitochondria while the other is found in the cytosol. The mitochondrial...

The Utility of Superoxide Dismutase in Studying Free Radical Reactions

The superoxide dismutase (dismutase) which has already been found to be useful in detecting the role of O2·- in certain enzymic reactions has here been shown to be applicable to...

A Direct Demonstration of the Catalytic Action of Superoxide Dismutase through the Use of Pulse Radiolysis

Abstract Superoxide dismutase catalyzes the decay of O2-, generated by pulse radiolysis. The enzymatic reaction was first order with respect to enzyme and to O2- and the rate co...

THE ROLE OF O₂^‐ IN THE CHEMILUMINESCENCE OF LUMINOL*

Abstract— The chemiluminescence of luminol in buffered aqueous solutions is inhibited by superoxide dismutase. This occurs whether the luminescence is induced by ferricyanide, p...

Superoxide radicals and phagocytosis

Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels

The Reduction of Cytochrome c by Milk Xanthine Oxidase

The reduction of cytochrome c by xanthine oxidase and the competitive inhibition of this process by carbonic anhydrase and by myoglobin have been studied by kinetic and by equil...

The Generation of Superoxide Radical during the Autoxidation of Ferredoxins

Electrolytic Univalent Reduction of Oxygen in Aqueous Solution Demonstrated with Superoxide Dismutase

The superoxide anion, generated electrolytically at a platinum electrode in buffered aqueous solution, was detected by its ability to cause the oxidation of epinephrine to adren...