Multicolor Spectral Karyotyping of Human Chromosomes

Abstract

The simultaneous and unequivocal discernment of all human chromosomes in different colors would be of significant clinical and biologic importance. Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization. By means of computer separation (classification) of spectra, spectrally overlapping chromosome-specific DNA probes could be resolved, and all human chromosomes were simultaneously identified.

Keywords

KaryotypeChromosomeFluorescence in situ hybridizationCentromereHuman genomeBiologyGeneticsHybridization probeCytogeneticsGenomeComputational biologyMolecular biologyDNAGene

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Publication Info

Year: 1996
Type: article
Volume: 273
Issue: 5274
Pages: 494-497
Citations: 1749
Access: Closed

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APA Style

                            
                                
                                    Evelin Schröck, 
                                
                                    Stanislas du Manoir, 
                                
                                    Timothy Veldman
                                
                                et al.
                            
                            (1996). 
                            Multicolor Spectral Karyotyping of Human Chromosomes. 
                            Science
                            , 273
                            (5274)
                            , 494-497.
                            https://doi.org/10.1126/science.273.5274.494
                        

Identifiers

DOI: 10.1126/science.273.5274.494