Keywords
PI3K/AKT/mTOR pathwayBiologyNeurodegenerationMechanistic target of rapamycinSignal transductionDiseaseNeuroscienceProtein kinase BCell biologyBioinformaticsMedicineInternal medicine
Affiliated Institutions
Related Publications
Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
Coordinating Metabolism Growth factors help to coordinate metabolism with growth in part by stimulating the activity of the protein kinase mTORC1 (mechanistic target of rapamyci...
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system
Inhibition of the mechanistic target of rapamycin (mTOR) signaling pathway by the FDA-approved drug rapamycin has been shown to promote lifespan and delay age-related diseases i...
mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
Proliferation Control The protein complex mTORC1, which contains the protein kinase known as mammalian target of rapamycin, is an important regulator of cell proliferation and c...
The Phosphoinositide 3-Kinase Pathway
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of ph...
Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin
The immunosuppressant rapamycin interferes with G 1 -phase progression in lymphoid and other cell types by inhibiting the function of the mammalian target of rapamycin (mTOR). m...
Publication Info
- Year
- 2012
- Type
- review
- Volume
- 149
- Issue
- 2
- Pages
- 274-293
- Citations
- 8207
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
8207
OpenAlex
Cite This
Mathieu Laplante,
David M. Sabatini
(2012).
mTOR Signaling in Growth Control and Disease.
Cell
, 149
(2)
, 274-293.
https://doi.org/10.1016/j.cell.2012.03.017
Identifiers
- DOI
- 10.1016/j.cell.2012.03.017