Whitehead Institute for Biomedical Research

Hallmarks of Cancer: The Next Generation

MicroRNAs

Initial sequencing and analysis of the human genome

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collabor...

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or for assigning tumo...

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

The basics of epithelial-mesenchymal transition

The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understoo...

Understanding the tumor immune microenvironment (TIME) for effective therapy

The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical r...

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

Copper induces cell death by targeting lipoylated TCA cycle proteins

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. H...

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer