Todd R. Golub

Copper induces cell death by targeting lipoylated TCA cycle proteins

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. H...

Next-generation characterization of the Cancer Cell Line Encyclopedia

Genome-Wide Views of Cancer

Nearly coincident with the publication of the article by Hedenfalk et al.1 in this issue of the Journal are reports of the complete DNA sequence of the human genome.2,3 This rem...

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or for assigning tumo...

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation

Array technologies have made it straightforward to monitor simultaneously the expression pattern of thousands of genes. The challenge now is to interpret such massive data sets....

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

MicroRNA expression profiles classify human cancers

Multiclass cancer diagnosis using tumor gene expression signatures

The optimal treatment of patients with cancer depends on establishing accurate diagnoses by using a complex combination of clinical and histopathological data. In some instances...

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

Gene expression–based high-throughput screening(GE-HTS) and application to leukemia differentiation

The landscape of somatic copy-number alteration across human cancers

Melanoma genome sequencing reveals frequent PREX2 mutations