John M. Asara

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Controlling supplies for DNA and RNA synthesis The mTORC1 protein kinase complex regulates anabolic metabolism and coordinates cellular signals that promote growth with availabi...

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

Coordinating Metabolism Growth factors help to coordinate metabolism with growth in part by stimulating the activity of the protein kinase mTORC1 (mechanistic target of rapamyci...

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability. In the presence of oxygen, HIF is ta...