mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Abstract

Controlling supplies for DNA and RNA synthesis The mTORC1 protein kinase complex regulates anabolic metabolism and coordinates cellular signals that promote growth with availability of required precursor metabolites. Signaling through mTORC1 controls pyrimidine synthesis. Ben-Sahra et al. found that mTORC1 also functions by a different mechanism to regulate purine biosynthesis, thus generating precursors for the synthesis of RNA and DNA (see the Perspective by Ma and Jones). Signaling by mTORC1 caused accumulation of the transcription factor ATF4, which enhances production of the enzyme methylenetetrahydrofolate dehydrogenase 2, thus leading to increased production of the purine nucleotides needed for cell growth. Science , this issue p. 728 ; see also p. 670

Keywords

ChemistrymTORC1Cell biologyPurinePurine metabolismBiochemistryBiologyPhosphorylationEnzyme

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Publication Info

Year: 2016
Type: article
Volume: 351
Issue: 6274
Pages: 728-733
Citations: 760
Access: Closed

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APA Style

                            
                                
                                    Issam Ben‐Sahra, 
                                
                                    Gerta Hoxhaj, 
                                
                                    Stéphane J. H. Ricoult
                                
                                et al.
                            
                            (2016). 
                            mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. 
                            Science
                            , 351
                            (6274)
                            , 728-733.
                            https://doi.org/10.1126/science.aad0489
                        

Identifiers

DOI: 10.1126/science.aad0489