Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

Ivana Bjedov; Janne M. Toivonen; Fiona Kerr; Cathy Slack; Jake Jacobson; A. Reghan Foley; Linda Partridge

doi:10.1016/j.cmet.2009.11.010

Keywords

LongevityTOR signalingBiologyDrosophila melanogasterLife spanCell biologyModel organismAutophagyMutantDrosophila (subgenus)KinaseGeneticsGeneEvolutionary biology

Affiliated Institutions

Related Publications

Induced Overexpression of Mitochondrial Mn-Superoxide Dismutase Extends the Life Span of Adult <i>Drosophila melanogaster</i>

Jing‐Tao Sun , Donna G. Folk , Timothy J. Bradley +1 more

Abstract A transgenic system (“FLP-out”) based on yeast FLP recombinase allowed induced overexpression of MnSOD enzyme in adult Drosophila melanogaster. With FLP-out a brief hea...

2002 Genetics 377 citations

A connectome and analysis of the adult Drosophila central brain

Louis K. Scheffer , C. Shan Xu , Michał Januszewski +97 more

The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly ...

2020 eLife 1145 citations

A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster

Zhihao Zheng , J. Scott Lauritzen , Eric Perlman +20 more

Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-neuron brain is a large but tractable target for comprehensive neural circuit mapping....

2018 Cell 1093 citations

The immune response of <i>Drosophila melanogaster</i>

Vincent Leclerc , Jean‐Marc Reichhart

Summary: The response of the fruit fly Drosophila melanogaster to various microorganism infections relies on a multilayered defense. The epithelia constitute a first and efficie...

2004 Immunological Reviews 217 citations

Genetic pathways that regulate ageing in model organisms

Leonard Guarente , Cynthia Kenyon

Searches for genes involved in the ageing process have been made in genetically tractable model organisms such as yeast, the nematode Caenorhabditis elegans, Drosophila melanoga...

2000 Nature 1339 citations

Publication Info

Year: 2010
Type: article
Volume: 11
Issue: 1
Pages: 35-46
Citations: 1063
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1063

OpenAlex

Cite This

APA Style

                            
                                
                                    Ivana Bjedov, 
                                
                                    Janne M. Toivonen, 
                                
                                    Fiona Kerr
                                
                                et al.
                            
                            (2010). 
                            Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster. 
                            Cell Metabolism
                            , 11
                            (1)
                            , 35-46.
                            https://doi.org/10.1016/j.cmet.2009.11.010
                        

Identifiers

DOI: 10.1016/j.cmet.2009.11.010