Jean‐Marc Reichhart

The immune response of <i>Drosophila melanogaster</i>

Summary: The response of the fruit fly Drosophila melanogaster to various microorganism infections relies on a multilayered defense. The epithelia constitute a first and efficie...

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.

In this paper we report a recessive mutation, immune deficiency (imd), that impairs the inducibility of all genes encoding antibacterial peptides during the immune response of D...

Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient <i>Drosophila</i>

The antifungal defense of Drosophila is controlled by the spaetzle/Toll/cactus gene cassette. Here, a loss-of-function mutation in the gene encoding a blood serine protease inhi...

Drosophila Immune Deficiency (IMD) Is a Death Domain Protein that Activates Antibacterial Defense and Can Promote Apoptosis

The Rel Protein DIF Mediates the Antifungal but Not the Antibacterial Host Defense in Drosophila

Activation of <i>Drosophila</i> Toll During Fungal Infection by a Blood Serine Protease

Drosophila host defense to fungal and Gram-positive bacterial infection is mediated by the Spaetzle/Toll/cactus gene cassette. It has been proposed that Toll does not function a...