Abstract
We found an average difference between observed and true vaccine effectiveness of -11.9%. Observed vaccine effectiveness underestimated the true effectiveness in 88% of model iterations. Diagnostic test specificity exhibited the strongest association with observed vaccine effectiveness, followed by the likelihood of receiving a diagnostic test based on vaccination status and the likelihood that a child hospitalized with acute respiratory infection had influenza. Our findings suggest that the potential biases in case-control studies that we examined tend to result in underestimates of true influenza vaccine effects.
Keywords
MedicineVaccinationMagnitude (astronomy)VirologyImmunologyStatistics
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Publication Info
- Year
- 2011
- Type
- article
- Volume
- 54
- Issue
- 1
- Pages
- 25-32
- Citations
- 36
- Access
- Closed
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Cite This
Jill M. Ferdinands,
David K. Shay
(2011).
Magnitude of Potential Biases in a Simulated Case-Control Study of the Effectiveness of Influenza Vaccination.
Clinical Infectious Diseases
, 54
(1)
, 25-32.
https://doi.org/10.1093/cid/cir750
Identifiers
- DOI
- 10.1093/cid/cir750