Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

Richard Wooster; Susan L. Neuhausen; Jonathan Mangion; Yvette Quirk; Deborah Ford; Nadine Collins; Kim Nguyễn; Sheila Seal; Thao Tran; D. Averill; Patty Fields; Gill Marshall; Steven A. Narod; Gilbert Lenoir; Henry T. Lynch; Jean Feunteun; Peter Devilee; Cees J. Cornelisse; Fred H. Menko; Peter A. Daly; W. Ormiston; Ross McManus; Carole Pye; Cathryn M. Lewis; Lisa Cannon‐Albright; Julian Peto; Bruce A.J. Ponder; Mark H. Skolnick; Douglas F. Easton; David E. Goldgar; Michael R. Stratton

doi:10.1126/science.8091231

Abstract

A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2 , to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1 , does not confer a substantially elevated risk of ovarian cancer.

Keywords

Breast cancerCentimorganLocus (genetics)GeneticsChromosome 17 (human)BiologyBRCA2 ProteinOvarian cancerGenetic linkageGeneCancerChromosomeGene mappingMutationGermline mutation

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Publication Info

Year: 1994
Type: article
Volume: 265
Issue: 5181
Pages: 2088-2090
Citations: 1881
Access: Closed

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APA Style

                            
                                
                                    Richard Wooster, 
                                
                                    Susan L. Neuhausen, 
                                
                                    Jonathan Mangion
                                
                                et al.
                            
                            (1994). 
                            Localization of a Breast Cancer Susceptibility Gene, <i>BRCA2</i> , to Chromosome 13q12-13. 
                            Science
                            , 265
                            (5181)
                            , 2088-2090.
                            https://doi.org/10.1126/science.8091231
                        

Identifiers

DOI: 10.1126/science.8091231

Localization of a Breast Cancer Susceptibility Gene, <i>BRCA2</i> , to Chromosome 13q12-13