Abstract
Klotho protein binds to fibroblast growth factor receptors and functions as a regulator of FGF23 signaling. It also functions as an enzyme that modifies sugar chains of transient receptor potential vanilloid-5 and regulates its activity. Klotho is a multi-functional protein that regulates phosphate/calcium metabolism as well as aging.
Keywords
KlothoCell biologyFibroblast growth factor 23Fibroblast growth factorTransient receptor potential channelReceptorChemistryCalciumEndocrinologyReabsorptionInternal medicineSignal transductionTRPV6BiologyBiochemistryParathyroid hormoneKidneyMedicine
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Publication Info
- Year
- 2006
- Type
- article
- Volume
- 15
- Issue
- 4
- Pages
- 437-441
- Citations
- 244
- Access
- Closed
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Cite This
Makoto Kuro‐o
(2006).
Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism.
Current Opinion in Nephrology & Hypertension
, 15
(4)
, 437-441.
https://doi.org/10.1097/01.mnh.0000232885.81142.83
Identifiers
- DOI
- 10.1097/01.mnh.0000232885.81142.83