Abstract

Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily‐conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status, growth factor and stress signals. Although TOR has been known as a key regulator of autophagy for more than a decade, the underlying regulatory mechanisms have not been clearly understood. This review discusses the recent advances in understanding of the mechanism by which TOR regulates autophagy with focus on mammalian TOR (mTOR) and its regulation of the autophagy machinery.

Keywords

AutophagyPI3K/AKT/mTOR pathwayRegulatorCell biologyTOR signalingBAG3BiologyMechanistic target of rapamycinULK1Master regulatorRPTORAutophagy-related protein 13Cell growthSignal transductionKinaseProtein kinase ABiochemistryTranscription factorApoptosisGeneProtein phosphorylation

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Publication Info

Year
2010
Type
review
Volume
584
Issue
7
Pages
1287-1295
Citations
2056
Access
Closed

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Chang Hwa Jung, Seung‐Hyun Ro, Jing Cao et al. (2010). mTOR regulation of autophagy. FEBS Letters , 584 (7) , 1287-1295. https://doi.org/10.1016/j.febslet.2010.01.017

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DOI
10.1016/j.febslet.2010.01.017