iTALK: an R Package to Characterize and Illustrate Intercellular Communication

Yuanxin Wang; Ruiping Wang; Shaojun Zhang; Shumei Song; Changying Jiang; Guangchun Han; Michael Wang; Jaffer A. Ajani; Andy Futreal; Linghua Wang

doi:10.1101/507871

Abstract

ABSTRACT Crosstalk between tumor cells and other cells within the tumor microenvironment (TME) plays a crucial role in tumor progression, metastases, and therapy resistance. We present iTALK, a computational approach to characterize and illustrate intercellular communication signals in the multicellular tumor ecosystem using single-cell RNA sequencing data. iTALK can in principle be used to dissect the complexity, diversity, and dynamics of cell-cell communication from a wide range of cellular processes.

Keywords

CrosstalkMulticellular organismTumor microenvironmentTumor cellsIntracellularBiologyCellCell biologyTumor progressionComputational biologyComputer scienceCancer researchCancerGeneticsEngineeringElectronic engineering

Affiliated Institutions

The University of Texas MD Anderson Cancer Center US

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Publication Info

Year: 2019
Type: preprint
Citations: 332
Access: Closed

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APA Style

                            
                                    Yuanxin Wang, 
                                
                                    Ruiping Wang, 
                                
                                    Shaojun Zhang
                                
                                et al.
                            
                            (2019). 
                            iTALK: an R Package to Characterize and Illustrate Intercellular Communication. 
                            bioRxiv (Cold Spring Harbor Laboratory)
                            
                            .
                            https://doi.org/10.1101/507871

Identifiers

DOI: 10.1101/507871