Johanna A. Joyce

The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancers represent complex ecosystems comprising tumor cells and a multitude of non-cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment (TME)...

Microenvironmental regulation of tumor progression and metastasis

Microenvironmental regulation of metastasis

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Alternative activation of tumor-associated macrophages by IL-4

Although macrophages were originally recognized as major immune effector cells, it is now appreciated that they also play many important roles in the maintenance of tissue homeo...

Therapeutic Targeting of the Tumor Microenvironment

Abstract Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a promising approach for cancer treatment in recent years due to the critical role...