Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance

Kwasi G. Mawuenyega; Carlos Cruchaga; Alison Goate; Kelly R. Bales; Steven M. Paul; Randall J. Bateman; David M. Holtzman; Joseph M. Castellano; Jungsu Kim; Floy R. Stewart; Hong Jiang; Ronald B. DeMattos; Bruce W. Patterson; Anne M. Fagan; John C. Morris

doi:10.1126/scitranslmed.3002156

Abstract

Human apoE4 increases the concentration of soluble Aβ in the brain by impairing its clearance.

Keywords

Gene isoformPeptideApolipoprotein EAmyloid (mycology)Human brainAmyloid βP3 peptideChemistryNeuroscienceCell biologyAmyloid precursor proteinBiologyBiochemistryMedicineAlzheimer's diseaseInternal medicinePathologyDiseaseGene

MeSH Terms

AdultAgedAllelesAlzheimer DiseaseAmyloid beta-PeptidesAnimalsApolipoprotein E4BiomarkersBrainFemaleGenotypeHumansMaleMiceMiceInbred C57BLMiceTransgenicMicrodialysisMiddle AgedProtein Isoforms

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Publication Info

Year: 2011
Type: article
Volume: 3
Issue: 89
Pages: 89ra57-89ra57
Citations: 1147
Access: Closed

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APA Style

                            
                                
                                    Kwasi G. Mawuenyega, 
                                
                                    Carlos Cruchaga, 
                                
                                    Alison Goate
                                
                                et al.
                            
                            (2011). 
                            Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance. 
                            Science Translational Medicine
                            , 3
                            (89)
                            , 89ra57-89ra57.
                            https://doi.org/10.1126/scitranslmed.3002156
                        

Identifiers

DOI: 10.1126/scitranslmed.3002156
PMID: 21715678
PMCID: PMC3192364

Data Quality

Data completeness: 86%