Steven M. Paul

Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

α2 Macroglobulin and the risk of Alzheimer’s disease

Our data support an association between the A2M gene and AD. This association is less pronounced, however, in our cohort than in the previously reported sample of sibpairs.

Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance

Human apoE4 increases the concentration of soluble Aβ in the brain by impairing its clearance.

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

sorLA (sorting protein-related receptor) is a type-1 membrane protein of unknown function that is expressed in neurons. Its homology to sorting receptors that shuttle between th...