Abstract
Lymphocyte subsets home in a particular manner depending on their class, state of activation and 'allegiance' to certain tissues. Naive lymphocytes home preferentially through lymphoid tissues, whereas effector and memory cells home preferentially through non-lymphoid tissues and exist as phenotypically distinct subsets with preferential localization to gut, skin or other tissues. These migration pathways, which correlate with different functional properties of lymphocyte subsets, increase the efficiency of the immune system.
Keywords
Homing (biology)EffectorLymphocyte homing receptorBiologyLymphocyte subsetsImmunologyImmune systemAddressinLymphatic systemCell biologyT cellGeneticsCellCell adhesion
MeSH Terms
AnimalsCell AdhesionCell Adhesion MoleculesCell MovementEndotheliumVascularHumansImmunologic MemoryInflammationIntestinesLymphocyte SubsetsLymphoid TissueOrgan SpecificityReceptorsLymphocyte HomingSkin
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Publication Info
- Year
- 1993
- Type
- review
- Volume
- 5
- Issue
- 3
- Pages
- 423-427
- Citations
- 284
- Access
- Closed
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Cite This
Charles R. Mackay
(1993).
Homing of naive, memory and effector lymphocytes.
Current Opinion in Immunology
, 5
(3)
, 423-427.
https://doi.org/10.1016/0952-7915(93)90063-x
Identifiers
- DOI
- 10.1016/0952-7915(93)90063-x
- PMID
- 8347302