Abstract
The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (T CM ) and effector memory (T EM ) cells characterized by distinct homing capacity and effector function. This review addresses the heterogeneity of T CM and T EM , their differentiation stages, and the current models for their generation and maintenance in humans and mice.
Keywords
EffectorBiologyHoming (biology)Function (biology)Memory cellAntigenNeuroscienceCell biologyImmunology
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Publication Info
- Year
- 2004
- Type
- review
- Volume
- 22
- Issue
- 1
- Pages
- 745-763
- Citations
- 2995
- Access
- Closed
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Cite This
Federica Sallusto,
Jens Geginat,
Antonio Lanzavecchia
(2004).
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance.
Annual Review of Immunology
, 22
(1)
, 745-763.
https://doi.org/10.1146/annurev.immunol.22.012703.104702
Identifiers
- DOI
- 10.1146/annurev.immunol.22.012703.104702