Charles R. Mackay

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

Chemokines and their receptors are important elements for the selective attraction of various subsets of leukocytes. To better understand the selective migration of functional s...

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

There is growing evidence that T helper cell subsets (T H 1 and T H 2) can be differentially recruited to promote different types of inflammatory reactions. Murine T H 1 but not...

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

In this report, we have addressed two questions concerning immunological memory: the way in which naive and memory T cells recirculate through the body, and the intrinsic rate o...

CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

Chemokine receptors serve as coreceptors for HIV entry into CD4+ cells. Their expression is thought to determine the tropism of viral strains for different cell types, and also ...

Homing of naive, memory and effector lymphocytes

Lymphocyte subsets home in a particular manner depending on their class, state of activation and 'allegiance' to certain tissues. Naive lymphocytes home preferentially through l...