Abstract

Chronic diuretic use was associated with increased long-term mortality and hospitalizations in a wide spectrum of ambulatory chronic systolic and diastolic HF patients. The findings of the current study challenge the wisdom of routine chronic use of diuretics in HF patients who are asymptomatic or minimally symptomatic without fluid retention, and are on complete neurohormonal blockade. These findings, based on a non-randomized design, need to be further studied in randomized trials.

Keywords

MedicineDiureticHeart failureHazard ratioInternal medicineLoop diureticAmbulatoryConfidence intervalProportional hazards modelFurosemideCardiology

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Publication Info

Year
2006
Type
article
Volume
27
Issue
12
Pages
1431-1439
Citations
455
Access
Closed

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Ali Ahmed, Ahsan Husain, Thomas E. Love et al. (2006). Heart failure, chronic diuretic use, and increase in mortality and hospitalization: an observational study using propensity score methods. European Heart Journal , 27 (12) , 1431-1439. https://doi.org/10.1093/eurheartj/ehi890

Identifiers

DOI
10.1093/eurheartj/ehi890