Abstract
The addition of enalapril to conventional therapy significantly reduced mortality and hospitalizations for heart failure in patients with chronic congestive heart failure and reduced ejection fractions.
Keywords
EnalaprilHeart failureMedicineCardiologyInternal medicineEjection fractionACE inhibitorAngiotensin-converting enzymeBlood pressure
MeSH Terms
Blood PressureCause of DeathChronic DiseaseDouble-Blind MethodElectrolytesEnalaprilFemaleFollow-Up StudiesHeart FailureHospitalizationHumansKidneyMaleMiddle AgedPatient ComplianceStroke VolumeSurvival Rate
Related Publications
Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions
The angiotensin-converting--enzyme inhibitor enalapril significantly reduced the incidence of heart failure and the rate of related hospitalizations, as compared with the rates ...
Comparison of Omapatrilat and Enalapril in Patients With Chronic Heart Failure
Background— Combined inhibition of the angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) may produce greater benefits in heart failure than ACE inhibition alon...
Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease
In chronic heart failure, a diuretic plus an angiotensin-converting enzyme (ACE) inhibitor only partially suppresses aldosterone despite the fact that aldosterone has many harmf...
Mortality and Morbidity Reduction With Candesartan in Patients With Chronic Heart Failure and Left Ventricular Systolic Dysfunction
Background— Patients with symptomatic chronic heart failure (CHF) and reduced left ventricular ejection fraction (LVEF) have a high risk of death and hospitalization for CHF det...
Immediate and sustained hemodynamic and clinical improvement in chronic heart failure by an oral angiotensin-converting enzyme inhibitor.
The hemodynamic effects of an oral angiotensin-converting enzyme inhibitor, captopril, were evaluated in 10 symptomatic patients with chronic congestive heart failure. In all pa...
Publication Info
- Year
- 1991
- Type
- article
- Volume
- 325
- Issue
- 5
- Pages
- 293-302
- Citations
- 7997
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
7997
OpenAlex
104
Influential
5759
CrossRef
Cite This
The SOLVD Investigators
(1991).
Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure.
New England Journal of Medicine
, 325
(5)
, 293-302.
https://doi.org/10.1056/nejm199108013250501
Identifiers
- DOI
- 10.1056/nejm199108013250501
- PMID
- 2057034