Immediate and sustained hemodynamic and clinical improvement in chronic heart failure by an oral angiotensin-converting enzyme inhibitor.

Abstract

The hemodynamic effects of an oral angiotensin-converting enzyme inhibitor, captopril, were evaluated in 10 symptomatic patients with chronic congestive heart failure. In all patients there was a significant increase in cardiac output (average 28%), stroke volume (49%), and stroke work index (26%), along with a decrease in pulmonary capillary wedge pressure (48%), indicating improved left ventricular function. Modest decreases in heart rate and arterial pressure were also observed. In seven patients maintained on captopril therapy, repeat hemodynamic studies at 2 months revealed sustained effects. These beneficial hemodynamic effects were accompanied by clinical improvement and improved exercise tolerance during maintenance therapy. These findings suggest that captopril may be a useful therapeutic adjunct for the long-term management of patients with chronic congestive heart failure.

Keywords

MedicineCaptoprilPulmonary wedge pressureHeart failureHemodynamicsCardiologyInternal medicineStroke volumeCardiac indexCardiac outputAngiotensin-converting enzymeBlood pressureACE inhibitorHeart rateEjection fraction

MeSH Terms

AdministrationOralAdultAgedAngiotensin-Converting Enzyme InhibitorsBlood PressureCaptoprilCardiac OutputChronic DiseaseFemaleFollow-Up StudiesHeart FailureHeart RateHemodynamicsHumansMaleMiddle AgedProlineVascular Resistance

Related Publications

Captopril Treatment of Chronic Heart Failure in the Very Old

Veerle De Bock , Tony Mets , Marco Romagnoli +1 more

The study gives further evidence that angiotensin-converting enzyme inhibitor treatment for very old patients with chronic heart failure is useful.

1994 Journal of Gerontology 24 citations

Reproducibility and responsiveness of quality of life assessment and six minute walk test in elderly heart failure patients

Shaun T. O’Keeffe , Michael Lye , Claire Donnellan +1 more

Objective To examine the reproducibility and responsiveness to change of a six minute walk test and a quality of life measure in elderly patients with heart failure. Design Long...

1998 Heart 254 citations

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

Salim Yusuf , Peter Sleight , Janice Pogue +3 more

Ramipril significantly reduces the rates of death, myocardial infarction, and stroke in a broad range of high-risk patients who are not known to have a low ejection fraction or ...

2000 New England Journal of Medicine 8597 citations

Clinical Presentation and Outcome in a Contemporary Cohort of Patients With Acute Myocarditis

Enrico Ammirati , Manlio Cipriani , Claudio Moro +35 more

Background: There is controversy about the outcome of patients with acute myocarditis (AM), and data are lacking on how patients admitted with suspected AM are managed. We repor...

2018 Circulation 396 citations

Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2

Carlos M. Ferrario , Jewell A. Jessup , Mark C. Chappell +5 more

Background— Angiotensin-converting enzyme 2 (ACE2) has emerged as a novel regulator of cardiac function and arterial pressure by converting angiotensin II (Ang II) into the vaso...

2005 Circulation 1598 citations

Publication Info

Year: 1980
Type: article
Volume: 61
Issue: 5
Pages: 931-937
Citations: 292
Access: Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric

Immediate and sustained hemodynamic and clinical improvement in chronic heart failure by an oral angiotensin-converting enzyme inhibitor.

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

292

OpenAlex

Influential

Cite This

APA Style

                            
                                
                                    Robert Ader, 
                                
                                    Kanu Chatterjee, 
                                
                                    Thomas A. Ports
                                
                                et al.
                            
                            (1980). 
                            Immediate and sustained hemodynamic and clinical improvement in chronic heart failure by an oral angiotensin-converting enzyme inhibitor.. 
                            Circulation
                            , 61
                            (5)
                            , 931-937.
                            https://doi.org/10.1161/01.cir.61.5.931
                        

Identifiers

DOI: 10.1161/01.cir.61.5.931
PMID: 6244906

Data Quality

Data completeness: 86%