Generalized Potential of Adult Neural Stem Cells

Diana L. Clarke; Clas B. Johansson; Johannes Wilbertz; Biborka Veress; Erik Nilsson; Helena Karlström; Urban Lendahl; Jonas Frisén

doi:10.1126/science.288.5471.1660

Abstract

The differentiation potential of stem cells in tissues of the adult has been thought to be limited to cell lineages present in the organ from which they were derived, but there is evidence that some stem cells may have a broader differentiation repertoire. We show here that neural stem cells from the adult mouse brain can contribute to the formation of chimeric chick and mouse embryos and give rise to cells of all germ layers. This demonstrates that an adult neural stem cell has a very broad developmental capacity and may potentially be used to generate a variety of cell types for transplantation in different diseases.

Keywords

Stem cellBiologyNeural stem cellAdult stem cellCell biologyCellular differentiationTransplantationCell typeNeurosphereNeuroscienceCellGeneticsMedicineInternal medicineGene

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Publication Info

Year: 2000
Type: letter
Volume: 288
Issue: 5471
Pages: 1660-1663
Citations: 1070
Access: Closed

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APA Style

                            
                                
                                    Diana L. Clarke, 
                                
                                    Clas B. Johansson, 
                                
                                    Johannes Wilbertz
                                
                                et al.
                            
                            (2000). 
                            Generalized Potential of Adult Neural Stem Cells. 
                            Science
                            , 288
                            (5471)
                            , 1660-1663.
                            https://doi.org/10.1126/science.288.5471.1660
                        

Identifiers

DOI: 10.1126/science.288.5471.1660