Abstract

Microfluidic devices are finding increasing application as analytical systems, biomedical devices, tools for chemistry and biochemistry, and systems for fundamental research. Conventional methods of fabricating microfluidic devices have centered on etching in glass and silicon. Fabrication of microfluidic devices in poly(dimethylsiloxane) (PDMS) by soft lithography provides faster, less expensive routes than these conventional methods to devices that handle aqueous solutions. These soft-lithographic methods are based on rapid prototyping and replica molding and are more accessible to chemists and biologists working under benchtop conditions than are the microelectronics-derived methods because, in soft lithography, devices do not need to be fabricated in a cleanroom. This paper describes devices fabricated in PDMS for separations, patterning of biological and nonbiological material, and components for integrated systems.

Keywords

MicrofluidicsCleanroomSoft lithographyNanotechnologyFabricationMicroelectronicsLithographyMaterials scienceReplicaRapid prototypingPhotolithographyEtching (microfabrication)Molding (decorative)Optoelectronics

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Publication Info

Year
2000
Type
review
Volume
21
Issue
1
Pages
27-40
Citations
3165
Access
Closed

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J. Cooper McDonald, David Cameron Duffy, Janelle R. Anderson et al. (2000). Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis , 21 (1) , 27-40. https://doi.org/10.1002/(sici)1522-2683(20000101)21:1<27::aid-elps27>3.0.co;2-c

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DOI
10.1002/(sici)1522-2683(20000101)21:1<27::aid-elps27>3.0.co;2-c