Abstract

The efficacy of ampicillin bound to polyisohexylcyanoacrylate nanoparticles was studied in vitro in mouse peritoneal macrophages infected with Listeria monocytogenes. Nanoparticles containing ampicillin 1 mg/L were more effective after 30 h than free ampicillin at the same concentration, with viable counts of 3.68 and 5.43 log10 cfu/mL, respectively. The nanoparticles acted on the intracellular bacteria after a lag period of 6-9 h; this time was apparently required for the degradation of the polymer. At the doses used in these experiments, empty nanoparticles had neither an anti-listeria nor a cytotoxic effect.

Keywords

Listeria monocytogenesAmpicillinMicrobiologyListeriaIn vitroChemistryIntracellularBacteriaNanoparticleCytotoxicityBiologyAntibioticsBiochemistryMaterials scienceNanotechnology

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Publication Info

Year
1992
Type
article
Volume
30
Issue
2
Pages
173-179
Citations
64
Access
Closed

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Francoise Forestier, Pascal Gerrier, Catherine Chaumanrd et al. (1992). Effect of nanoparticle-bound ampicillin on the survival of <i>Listeria monocytogenes</i> in mouse peritoneal macrophages. Journal of Antimicrobial Chemotherapy , 30 (2) , 173-179. https://doi.org/10.1093/jac/30.2.173

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DOI
10.1093/jac/30.2.173