Abstract

N6-methyladenosine (m6A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m6A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m6A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.

Keywords

N6-MethyladenosineRNABiologyMessenger RNATranscriptomeComputational biologyEnzymeMetabolismCell biologyBiochemistryGene expressionGeneMethyltransferase

MeSH Terms

AdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsHumansMethyltransferasesRNARNA IsoformsRNAMessengerRNA-Binding ProteinsTranscriptome

Affiliated Institutions

Related Publications

Publication Info

Year
2018
Type
review
Volume
28
Issue
6
Pages
616-624
Citations
1681
Access
Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1681
OpenAlex
0
Influential

Cite This

Ying Yang, Phillip J. Hsu, Yusheng Chen et al. (2018). Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism. Cell Research , 28 (6) , 616-624. https://doi.org/10.1038/s41422-018-0040-8

Identifiers

DOI
10.1038/s41422-018-0040-8
PMID
29789545
PMCID
PMC5993786

Data Quality

Data completeness: 86%