Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

Christopher G. Willett; Yves Boucher; Emmanuelle di Tomaso; Dan G. Duda; Lance L. Munn; Ricky T. Tong; Daniel C. Chung; Dushyant V. Sahani; Sanjeeva P. Kalva; Sergey V. Kozin; Mari Mino; Kenneth S. Cohen; David T. Scadden; Alan C. Hartford; Alan J. Fischman; Jeffrey W. Clark; David P. Ryan; Andrew X. Zhu; Lawrence S. Blaszkowsky; Helen X Chen; Paul C. Shellito; Gregory Y. Lauwers; Rakesh K. Jain

doi:10.1038/nm988

Abstract

The effects of vascular endothelial growth factor (VEGF) blockade on the vascular biology of human tumors are not known. Here we show here that a single infusion of the VEGF-specific antibody bevacizumab decreases tumor perfusion, vascular volume, microvascular density, interstitial fluid pressure and the number of viable, circulating endothelial and progenitor cells, and increases the fraction of vessels with pericyte coverage in rectal carcinoma patients. These data indicate that VEGF blockade has a direct and rapid antivascular effect in human tumors.

Keywords

BevacizumabBlockadeColorectal cancerVascular endothelial growth factorPericyteMedicineCancer researchAngiogenesisPerfusionAntibodyVEGF receptorsMural cellProgenitor cellVascular endothelial growth factor ACancerEndothelial stem cellPathologyInternal medicineImmunologyBiologyStem cellChemotherapyReceptorVascular smooth muscleIn vitroCell biology

MeSH Terms

AdenocarcinomaAngiogenesis InhibitorsAntibodiesMonoclonalAntibodiesMonoclonalHumanizedBevacizumabHumansRectal NeoplasmsVascular Endothelial Growth Factor A

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Publication Info

Year: 2004
Type: article
Volume: 10
Issue: 2
Pages: 145-147
Citations: 1939
Access: Closed

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APA Style

                            
                                
                                    Christopher G. Willett, 
                                
                                    Yves Boucher, 
                                
                                    Emmanuelle di Tomaso
                                
                                et al.
                            
                            (2004). 
                            Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. 
                            Nature Medicine
                            , 10
                            (2)
                            , 145-147.
                            https://doi.org/10.1038/nm988
                        

Identifiers

DOI: 10.1038/nm988
PMID: 14745444
PMCID: PMC2693485

Data Quality

Data completeness: 90%