Developing a New Definition and Assessing New Clinical Criteria for Septic Shock

Abstract

Based on a consensus process using results from a systematic review, surveys, and cohort studies, septic shock is defined as a subset of sepsis in which underlying circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than sepsis alone. Adult patients with septic shock can be identified using the clinical criteria of hypotension requiring vasopressor therapy to maintain mean BP 65 mm Hg or greater and having a serum lactate level greater than 2 mmol/L after adequate fluid resuscitation.

Keywords

Affiliated Institutions

• Rhode Island Hospital US
• Guy's and St Thomas' NHS Foundation Trust GB
• University of Pittsburgh US
• Feinstein Institute for Medical Research US
• Health Sciences Centre CA
• Kaiser Permanente US
• King's College London GB
• Hofstra University US
• University College London GB
• The Ohio State University US
• University of Toronto CA
• Bury College GB
• Brown University US
• Schneider Children's Hospital US
• Sunnybrook Health Science Centre CA
• Cohen Children's Medical Center US

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