Sunnybrook Health Science Centre

Dabigatran versus Warfarin in Patients with Atrial Fibrillation

In patients with atrial fibrillation, dabigatran given at a dose of 110 mg was associated with rates of stroke and systemic embolism that were similar to those associated with w...

Surviving Sepsis Campaign

To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. A consensus committee of 68 internat...

The american college of rheumatology 1990 criteria for the classification of fibromyalgia

Abstract To develop criteria for the classification of fibromyalgia, we studied 558 consecutive patients: 293 patients with fibromyalgia and 265 control patients. Interviews and...

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer

In patients with previously untreated metastatic nonsquamous NSCLC without EGFR or ALK mutations, the addition of pembrolizumab to standard chemotherapy of pemetrexed and a plat...

A pragmatic–explanatory continuum indicator summary (PRECIS): a tool to help trial designers

2019 Canadian guideline for physical activity throughout pregnancy

The objective is to provide guidance for pregnant women and obstetric care and exercise professionals on prenatal physical activity. The outcomes evaluated were maternal, fetal ...

An introduction to reading and appraising qualitative research

This article explores the difference between qualitative and quantitative research and the need for doctors to be able to interpret and appraise qualitative research

Are History and Physical Examination a Good Screening Test for Sleep Apnea?

In patients with a high predicted probability of the sleep apnea syndrome, subjective impression alone or any combination of clinical features cannot serve as a reliable screeni...

The experience and impact of chronic disease peer support interventions: A qualitative synthesis

This synthesis suggests that those developing and implementing peer support interventions need to be sensitive to their potential negative effects. They will need to manage the ...

Positive predictive value of device-detected atrial high-rate episodes at different rates and durations: An analysis from ASSERT