Abstract
Abstract In Drosophila, the response against various microorganisms involves different recognition and signaling pathways, as well as distinct antimicrobial effectors. On the one hand, the immune deficiency pathway regulates the expression of antimicrobial peptides that are active against Gram-negative bacteria. On the other hand, the Toll pathway is involved in the defense against filamentous fungi and controls the expression of antifungal peptide genes. The gene coding for the only known peptide with high activity against Gram-positive bacteria, Defensin, is regulated by both pathways. So far, survival experiments to Gram-positive bacteria have been performed with Micrococcus luteus and have failed to reveal the involvement of one or the other pathway in host defense against such infections. In this study, we report that the Toll pathway, but not that of immune deficiency, is required for resistance to other Gram-positive bacteria and that this response does not involve Defensin.
Keywords
Micrococcus luteusBiologyDefensinEffectorMicrobiologyBacteriaImmune systemInnate immune systemGram-negative bacteriaAntimicrobial peptidesGeneAntimicrobialBeta defensinGeneticsCell biologyEscherichia coliStaphylococcus aureus
Affiliated Institutions
Related Publications
Toll-Like Receptors
The innate immune system in drosophila and mammals senses the invasion of microorganisms using the family of Toll receptors, stimulation of which initiates a range of host defen...
Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2
Abstract Invasive infection with Gram-positive and Gram-negative bacteria often results in septic shock and death. The basis for the earliest steps in innate immune response to ...
Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
Toll-like receptor (TLR) 2 and TLR4 are implicated in the recognition of various bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo roles o...
Bactericidal Kinetics of 3 Lactoferricins Against Staphylococcus aureus and Escherichia coli
Bovine lactoferricin is an antimicrobial, cationic peptide generated upon gastric pepsin cleavage of bovine lactoferrin. We investigated the bactericidal effects of native lacto...
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
Macrophages orchestrate innate immunity by phagocytosing pathogens and coordinating inflammatory responses. Effective defence requires the host to discriminate between different...
Publication Info
- Year
- 2002
- Type
- article
- Volume
- 168
- Issue
- 4
- Pages
- 1542-1546
- Citations
- 238
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
238
OpenAlex
Cite This
Sophie Rutschmann,
Ahmet Selçuk Kılınç,
Dominique Ferrandon
(2002).
Cutting Edge: The <i>Toll</i> Pathway Is Required for Resistance to Gram-Positive Bacterial Infections in <i>Drosophila</i>.
The Journal of Immunology
, 168
(4)
, 1542-1546.
https://doi.org/10.4049/jimmunol.168.4.1542
Identifiers
- DOI
- 10.4049/jimmunol.168.4.1542