Shizuo Akira

IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection

NF-IL6 was originally identified as a DNA-binding protein responsible for IL-1-stimulated IL-6 induction. Direct cloning of NF-IL6 revealed its homology with C/EBP. C/EBP is exp...

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Stimulation of Toll-like receptors (TLRs) triggers activation of a common MyD88-dependent signaling pathway as well as a MyD88-independent pathway that is unique to TLR3 and TLR...

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

Pathogen Recognition and Innate Immunity

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Toll-like receptors: critical proteins linking innate and acquired immunity

Innate immune recognition of viral infection

Toll‐like Receptor and RIG‐1‐like Receptor Signaling

Toll‐like receptors (TLRs) and RIG‐I‐like receptors (RLRs) constitute distinct families of pattern‐recognition receptors that sense nucleic acids derived from viruses and trigge...

A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells