Abstract
Summary The effects of intradermally injected prostaglandins (PGs) E 1 , E 2 , F 1α and F 2α have been examined in the rat and in man. PGE 1 and PGE 2 caused an increase in local vascular permeability in rat skin; their potency was comparable with that of other putative mediators of inflammation (histamine, bradykinin, and 5 ‐hydroxytryptamine), but PGF 1α and PGF 2α were only slightly active even at a dose of 1 μg. Prior administration of mepyramine and methysergide, or depletion of skin mast cell amines with compound 48/80, indicated that PGE 2 exerted its permeability effect in the rat by a release of mast cell amines. Nanogramme doses of PGE 1 and PGE 2 or microgramme doses of PGF 1α and PGF 2α injected intradermally into the human forearm induced weal and flare responses. It is concluded that prostaglandins E 1 and E 2 can act as intermediates in the production of hyperaemia and oedema resulting from cell damage in the rat and man.
Keywords
HistamineMethysergideMepyramineChemistryBradykininProstaglandin EIntradermal injectionVascular permeabilityEndocrinologyMast cellProstaglandinInternal medicineMetiamidePharmacologyMedicineImmunologyBiochemistryAntagonistReceptorHistamine H2 receptor
Affiliated Institutions
Related Publications
Recovery of Prostaglandins in Human Cutaneous Inflammation
An in-vivo skin perfusion technique has been used to study the pharmacological activity in inflamed skin of patients with allergic contact eczema. Perfusates from 35 out of 45 p...
ANALGESIC ANTIPYRETIC DRUGS AS ANTAGONISTS OF BRADYKININ
The antagonism between analgesic antipyretic drugs and bradykinin was examined quantitatively, using the bronchoconstrictor response of guinea‐pigs in vivo . The dose of bradyki...
A SENSITIVE METHOD FOR THE ASSAY OF 5‐HYDROXYTRYPTAMINE
The movements of a strip of fundus from a rat stomach, suspended in a 5 ml. bath at 37°, are recorded by a spring‐loaded lever. The muscle is stretched for 15 to 30 sec. between...
Hydrocortisone Preserves the Vascular Barrier by Protecting the Endothelial Glycocalyx
Background Hydrocortisone protects against ischemia-reperfusion injury, reduces paracellular permeability for macromolecules, and is routinely applied in the prevention of inter...
Rat brain vascular distribution of interleukin‐1 type‐1 receptor immunoreactivity: Relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli
Abstract Interleukin‐1β (IL‐1β) is thought to act on the brain to induce fever, neuroendocrine activation, and behavioral changes during disease through induction of prostagland...
Publication Info
- Year
- 1971
- Type
- article
- Volume
- 41
- Issue
- 1
- Pages
- 49-56
- Citations
- 333
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
333
OpenAlex
Cite This
Pearl Crunkhorn,
A.L. Willis
(1971).
Cutaneous reactions to intradermal prostaglandins.
British Journal of Pharmacology
, 41
(1)
, 49-56.
https://doi.org/10.1111/j.1476-5381.1971.tb09934.x
Identifiers
- DOI
- 10.1111/j.1476-5381.1971.tb09934.x