Abstract

An in-vivo skin perfusion technique has been used to study the pharmacological activity in inflamed skin of patients with allergic contact eczema. Perfusates from 35 out of 45 patients contained a smooth-muscle-contracting agent with prostaglandin-like properties. Solvent partition followed by thinlayer chromatography revealed this activity to be due to a mixture of prostaglandins E and F. This direct evidence supports the view that prostaglandins mediate inflammation in man.

Keywords

InflammationProstaglandinIn vivoPerfusionProstaglandin EChemistryHuman skinProstaglandin E2PharmacologyMedicineInternal medicineBiochemistryBiology

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Publication Info

Year
1971
Type
article
Volume
2
Issue
5756
Pages
258-260
Citations
205
Access
Closed

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Malcolm W. Greaves, Jørgen Søndergaard, Wendy J. McDonald-Gibson (1971). Recovery of Prostaglandins in Human Cutaneous Inflammation. BMJ , 2 (5756) , 258-260. https://doi.org/10.1136/bmj.2.5756.258

Identifiers

DOI
10.1136/bmj.2.5756.258