Keywords
Affiliated Institutions
Related Publications
Most mammalian mRNAs are conserved targets of microRNAs
MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-transcriptional repression. Many sites that match the miRNA seed (nucleotides 2–7), parti...
Systematic discovery and characterization of fly microRNAs using 12 <i>Drosophila</i> genomes
MicroRNAs (miRNAs) are short regulatory RNAs that inhibit target genes by complementary binding in 3′ untranslated regions (3′ UTRs). They are one of the most abundant classes o...
Principles of MicroRNA–Target Recognition
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression in plants and animals. Although their biological importance has become clear, how they recognize and r...
The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution
Thousands of mammalian messenger RNAs are under selective pressure to maintain 7-nucleotide sites matching microRNAs (miRNAs). We found that these conserved targets are often hi...
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of <i>Drosophila</i> microRNAs
MicroRNA (miRNA) genes give rise to small regulatory RNAs in a wide variety of organisms. We used computational methods to predict miRNAs conserved among Drosophila species and ...
Publication Info
- Year
- 2005
- Type
- letter
- Volume
- 120
- Issue
- 1
- Pages
- 15-20
- Citations
- 11777
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1016/j.cell.2004.12.035