Alexander Stark

Principles of MicroRNA–Target Recognition

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression in plants and animals. Although their biological importance has become clear, how they recognize and r...

Reliable prediction of regulator targets using 12 <i>Drosophila</i> genomes

Gene expression is regulated pre- and post-transcriptionally via cis -regulatory DNA and RNA motifs. Identification of individual functional instances of such motifs in genome s...

Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution

Evolution, biogenesis, expression, and target predictions of a substantially expanded set of <i>Drosophila</i> microRNAs

MicroRNA (miRNA) genes give rise to small regulatory RNAs in a wide variety of organisms. We used computational methods to predict miRNAs conserved among Drosophila species and ...

Systematic discovery and characterization of fly microRNAs using 12 <i>Drosophila</i> genomes

MicroRNAs (miRNAs) are short regulatory RNAs that inhibit target genes by complementary binding in 3′ untranslated regions (3′ UTRs). They are one of the most abundant classes o...

bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

Histone modifications at human enhancers reflect global cell-type-specific gene expression